Buy Selank Powder Peptide | Order Selank For Sale 10MG

Buy Selank Powder Peptide | 10MG

$33.00

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Clinical studies on selank show its potential for treating anxiety disorders. At Paradigm Peptides, certified, high quality selank for sale comes in 10mg vials. Research reports surrounding animal studies have found that selank has the ability to restore adrenaline, norepinephrine, and dopamine functions.

Selank from Paradigm Peptides comes in a 10 mg vial. It is a white lyophilized powder meant for studies and research purposes. This peptide is an artificial version of a natural tetrapeptide, called tuftsin.

Application: potential to restore adrenaline, norepinephrine, & dopamine functions
CAS: 129954-34-3
Molecular Weight: 751.89 Da (g/mol)
Chemical Formula: C33H57N11O9
Chemical Name: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Synonyms: Selanc
Storage: Minimize open air exposure, store in a cool dry place.
Stability: 2 years
Purity: 99%
Solubility: Soluble to water at rate of 1mg/ml
Physical Form: fine powder in glass vial
Specifications: 10mg vial
Terms: The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

Selank – What You Need to Know

Selank was developed by the Institute of Genetics of the Russian Academy of Science. It is considered a nootropic as well as a peptide because of its anxiolytic and nootropic tendencies. 

The Russian Academy of Science was able to combine tuftsin, a naturally occurring immunomodulatory peptide, with a stabilizing compound. In doing so, they essentially created a synthetic variation of this peptide that has a greater half life than its predecessor as well as improved metabolic stability. 

selank structure

Image: Side by side of tuftsin (naturally produced by the body) and selank (synthetic version of tuftsin).

Clinical Trials | Selank

Selank for Anxiety

For the purpose of testing the abilities of selank to reduce stress, male wistar rats were used in the noted clinical trial. In this trial, the anxiolytic activity of both selank and diazepam were tested against a lack of stressors and unpredictable chronic mild stress. The final data obtained from this particular trial concluded that selank was the most effective in “reducing anxiety in unpredictable chronic mild stress conditions”[1].

Memory & Learning with Selank

A clinical trial on outbred rats receiving ethanol as their only source of fluid was used in an effort to analyze the effects of selank on memory impairment. The rats that received the selank treatments intraperitoneally “produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol and prevented the formation of ethanol-induced memory and attention disturbances developing during alcohol withdrawal”[2]. The results from this specific clinical trial published in 2019 indicates selank has positive effects on age-related memory.

Selank Monoamines and Their Metabolites in Mice

The study investigated the impact of the heptapeptide selank on neurotransmitter monoamines and their metabolites in the brain structures of BALB/C and C57Bl/6 mice during the open-field test. Interstrain differences were observed in the content of norepinephrine (NE), dopamine (DA), serotonin (5-HT), and their metabolites in various brain regions.

Notably, BALB/C mice exhibited higher levels of 5-HT and its metabolite 5-oxyindolacetic acid in the hippocampus compared to C57Bl/6 mice. Selank administration (0.3 mg/kg) led to an increase in NE levels in the hypothalamus of both mouse strains. However, selank produced divergent effects on DA metabolites: concentrations of dioxyphenylacetic and homovanillic acids increased in the frontal cortex and hippocampus of C57Bl/6 mice but decreased in BALB/C mice. Additionally, selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice but did not affect these parameters in C57Bl/6 animals.

The results suggest the selectivity of selank’s anxiolytic effects based on the observed differential impact on neurotransmitter levels in the two mouse strains. [3]

Influence of Selank on the Level of Cytokines in Social Stress

The study aimed to explore the impact of Selank on cytokine levels in animals experiencing “social” stress. The chosen model involved confrontations between male rats to induce sensory stress. Rats were divided into three groups: intact males, animals subjected to 20 days of stress (sensory contact), and a group receiving intraperitoneal Selank during the 20-day stress period.

Results indicated a statistically significant increase in the levels of pro-inflammatory cytokines IL-1β, IL-6, and TGF-β1 in the serum of stressed animals. Although there was a tendency to decrease IL-4 concentration and increase TNF-α, these changes were not statistically significant. Selank administration during stress showed a notable effect, causing a decrease in IL-1β and IL-6 concentrations, restoration of IL-4 levels, and suppression of TGF-β1 and TNF-α production.

In conclusion, Selank demonstrated the ability to reduce the concentration of IL-1β, IL-6, and TNF-α, as well as TGF-β1, nearly reaching control values in the context of “social” stress. The study suggests the potential stress-protective activity of Selank and highlights the need for further research on cytokines’ role in stress-induced changes for optimal correction tools. [5]

Use of Selank to Correct Measures of Integrative Brain Activity and Biogenic Amine Levels in Rat Model

The study explored the impact of Selank, a heptapeptide with the active component Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and neurotransmitter levels in adult rats exposed to antenatal hypoxia during days 14–16 of gestation. Administering Selank intraperitoneally resulted in significant improvements in sensory attention levels and facilitated the learning process. 

Selank also normalized investigative activity levels in the open field and hole board tests. Importantly, it restored the balance of activity between the serotonergic and noradrenergic systems in the brain. These findings suggest that Selank may be beneficial in compensating for the enduring negative effects of antenatal hypoxia on brain integrative activity and the functioning of monoaminergic transmitter systems in adult rats. [6]

Other Resources:

[1] https://pubchem.ncbi.nlm.nih.gov/compound/11765600

[2] https://pubmed.ncbi.nlm.nih.gov/18577961/

[3] https://pubmed.ncbi.nlm.nih.gov/19093364/

[4] https://link.springer.com/article/10.1134%2FS0012496608040066

[5] https://www.ingentaconnect.com/content/ben/crcep/2021/00000016/00000002/art00007

[6] https://link.springer.com/article/10.1007/s11055-008-0030-2

Disclaimer: The selank currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease.

High Performance Liquid Chromatography | Selank

Selank HPLC

Certificate of Analysis | Selank

selank COA

 

Weight .25 oz
Dimensions 1 × 1 × 1 in
Weight

7 grams or .3 oz

Dimension

2"H x 1"W x 1"L