HCG is a synthetic peptide version of the hCG hormone that is commonly found in the placental cells during pregnancy. It’s primary role is to help with the overall development of the placenta.
| Application: | Helps in the secretion of progesterone |
| CAS: | 9002-61-3 |
| Molecular Weight: | 25719.70 g·mol |
| Chemical Formula: | C1105H1770N318O336S26 |
| Chemical Name: | N/A |
| Synonyms: | Chorionic Gonadotropin Human |
| Storage: | Minimize open air exposure, store in a cool dry place. |
| Stability: | 2 years |
| Purity: | 99% |
| Solubility: | Soluble to water at rate of 0.1mg/mL |
| Physical Form: | fine powder in glass vial |
| Specifications: | 5000iu vial |
| Terms: | The products we offer are intended for laboratory research use only. |
Behavioral Effects of hCG in Rat Model
The study explores the functional implications of luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors identified in different areas of the rat brain. Conducted on intact female rats during proestrus, the investigation administered hCG either intraperitoneally or intracerebroventricularly to evaluate its impact on brain arousal and responses to various stressors.
Peripheral administration of hCG resulted in prolonged sleeping time and reduced activity levels in the rats. These effects were mitigated when indomethacin, an inhibitor of prostaglandin synthesis, was co-administered, suggesting the involvement of prostaglandin pathways in mediating hCG’s effects. Specifically, hCG increased levels of immunoreactive prostaglandin D2 (PGD2) while decreasing levels of prostaglandin E2 (PGE2) in brain regions associated with activity and sleep regulation. [4]
Central administration of hCG led to decreased activity levels and exploratory behavior, along with reduced neophobia to taste and odor stimuli. Furthermore, hCG-treated rats exhibited lower levels of anxiety and higher maternal interest compared to control groups. Notably, hCG treatment also demonstrated a protective effect against stress-induced ulcers, which was reversed by pretreatment with antisense receptor oligonucleotide, indicating a direct hCG receptor-mediated effect. [4]
The findings suggest that hCG, capable of crossing the blood-brain barrier, exerts multifaceted effects on various behavioral patterns, reminiscent of anxiolytic treatments. These observations underscore the functional significance of LH/hCG receptors in the brain and hint at potential parallels between the behavioral responses observed in rats and those seen in pregnant women. Overall, the study sheds light on the complex interplay between hCG and brain function, opening avenues for further research.
hCG and LH Effects on Uterine Blood Flow in Rats
The study investigates the impact of luteinizing hormone (LH) and human chorionic gonadotropin (hCG) on uterine blood flow regulation via LH/hCG receptors present in uterine blood vessels. These receptors, predominantly found in smaller intramyometrial vessels and exhibiting cyclic activity, suggest a role in vascular regulation.
In pseudopregnant rats, hCG reduces uterine blood flow. Systemic administration of hCG to cycling rats promptly decreases uterine blood flow, a response absent in ovariectomized rats. Investigating microvascular responses, uterine arteriolar diameters were measured via videomicroscopy after direct hCG application or injection in rats across different estrous cycle stages. [5]
In diestrus rats, uterine arterioles dilated with hCG suffusion but constricted in proestrus. Intraperitoneal hCG injection induced arteriolar constriction in diestrus-2 and proestrus rats, but not in diestrus-1. Ovariectomy abolished hCG-induced arteriolar constriction, highlighting ovarian involvement in the response. The varied response suggests a dependence on both cycle stage and administration route. [5]
The study posits hCG’s direct or indirect modulation of uterine blood flow, potentially through the release of vasoactive substances or induction of angiogenesis. Overall, the findings underscore the intricate role of hCG in uterine vascular dynamics, shedding light on its regulatory mechanisms and potential implications for reproductive physiology in rats.
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Research:
[1] https://pubchem.ncbi.nlm.nih.gov/substance/56310665
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666719/
[3] https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.1995.tb05779.x
[4] https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2001-13918
[5] https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2001-13914
Disclaimer: The Chorionic Gonadotropin Human Peptide currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease. It is not intended for human consumption, and is for research purposes only.
| Weight | .30 oz |
|---|---|
| Dimensions | 2.5 × 1 × 1.5 in |
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