According to researchers, this polypeptide occurs in the pineal gland. It gets its name from its naturally occurring version which is called epithalamin. Epithalamin, like n-acetyl epitalon amidate, is an anti aging peptide. According to most research it activates telomerase which lengthens telomeres.
| Application: | Triggers rejuvenation of the whole body |
| CAS: | 307297-39-8 |
| Molecular Weight: | 390.349 g·mol |
| Chemical Formula: | C14H22N4O9 |
| Chemical Name: | Ala-Glu-Asp-Gly |
| Synonyms: | Epithalon, Epithalone, L-Alanyl-L-glutamyl-L-aspartyl-glycine, Epitalon |
| Storage: | Minimize open air exposure, store in a cool dry place. |
| Stability: | 2 years |
| Purity: | > 98% |
| Solubility: | Soluble to water at rate of 20mg/ml |
| Physical Form: | fine powder in glass vial |
| Specifications: | 50mg vial |
| Terms: | The products we offer are intended for laboratory research use only.
You will need to purchase Bacteriostatic water separately. |
N-Acetyl Epitalon Amidate is a synthetic peptide that has garnered attention for its potential therapeutic implications and anti-aging characteristics. It is derived from a longer peptide known as Epitalon, or epithalamin, composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. N-Acetyl Epitalon Amidate represents a modified form of Epitalon, featuring the addition of an acetyl group and an amide group aimed at enhancing its stability and bioavailability.
This peptide has captured scientific interest primarily due to its purported ability to modulate the production of telomerase, an enzyme pivotal in preserving the length of telomeres—the protective caps located at the termini of chromosomes. Telomeres undergo shortening with each cellular division, serving as a marker of cellular aging. By fostering telomerase activity, N-Acetyl Epitalon Amidate may potentially retard the aging process at the cellular level and conceivably prolong lifespan. Furthermore, it is speculated to possess antioxidant properties, potentially conferring protective effects against oxidative stress and age-associated degenerative processes.
Structure of N-Acetyl Epitalon Amidate
N-Acetyl Epitalon Amidate has a chemical structure that consists of four amino acids linked together by peptide bonds. The specific sequence of amino acids in N-Acetyl Epitalon Amidate is alanine-glutamic acid-aspartic acid-glycine. In addition, an acetyl group is attached to the amino terminus of the peptide, while an amide group is attached to the carboxyl terminus. These modifications enhance the stability and bioavailability of the peptide, making it more effective for therapeutic purposes.
The molecular structure of N-Acetyl Epitalon Amidate enables it to interact with cellular mechanisms involved in aging and oxidative stress, potentially exerting beneficial effects on overall health and longevity.
Mechanism of Action
The precise mechanism of action of N-Acetyl Epitalon Amidate is not fully understood, but it is believed to exert its effects through multiple pathways:
Regulation of Telomerase Activity: N-Acetyl Epitalon Amidate may stimulate the activity of telomerase, the enzyme responsible for maintaining the length of telomeres. By promoting telomerase activity, the peptide helps to preserve the integrity of telomeres and may slow down the cellular aging process.
Antioxidant Properties: N-Acetyl Epitalon Amidate possesses antioxidant properties, which enable it to neutralize harmful free radicals and reduce oxidative stress within cells. This antioxidant activity helps to protect cells from damage caused by reactive oxygen species, which are implicated in aging and various age-related diseases.
Regulation of Hormones: Some studies suggest that N-Acetyl Epitalon Amidate may modulate the secretion of certain hormones, such as melatonin and cortisol, which play crucial roles in regulating sleep-wake cycles, stress responses, and overall health.
N-Acetyl Epitalon Amidate appears to exert its anti-aging and health-promoting effects through a combination of mechanisms, including telomerase activation, antioxidant activity, and hormonal regulation.
Peptide Theory Of Aging In Comprehensive Tissue-Specific Studies
Delving into the intricacies of aging, a comprehensive study explores the potential of Mod N-Acetyl Epitalon Amidate and Epitalon in addressing age-related degeneration. The research highlights the development of biologically active peptide preparations from various tissues, shedding light on their rejuvenating effects across diverse organs.
Epitalon, a common tetrapeptide designed for the eye retina and pineal gland, mirrors the geroprotective properties of Epithalamin. Demonstrating its efficacy, Epitalon extends lifespan in mice and fruit flies, restores circadian rhythms in old rhesus monkeys, and enhances visual functions in rats with Retinitis Pigmentosa and patients with pigmental retinal degeneration. [2]
Moreover, short peptide preparations, including Mod N-Acetyl Epitalon Amidate, induce alterations in gene expression, suggesting their profound impact on aging mechanisms. The study postulates the peptide theory of aging, proposing that age-related changes in gene expression lead to impaired synthesis of regulatory peptides, ultimately manifesting as structural and functional alterations in organs and diseases. Correcting these imbalances with targeted peptide interventions may normalize bodily functions and mitigate age-related degeneration. [2]
Epithalamin And Epitalon: Novel Antioxidants Surpassing Melatonin In Old Rats
Examining the antioxidant potential of pineal gland peptides, particularly Epithalamin and Epitalon, the study unravels their remarkable efficacy in combating oxidative stress, surpassing even melatonin, a renowned antioxidant produced by the pineal gland.
Old rats subjected to peptide preparations underwent assessments of total antioxidant and antiradical activities, alongside measurements of antioxidant enzymes in blood serum, liver, and brain. Results unveiled the superior antioxidant effects of Epithalamin and Epitalon, which not only stimulated melatonin production but also exhibited distinct antioxidant mechanisms. Notably, Epithalamin showcased exceptional benefits by not only exerting direct antioxidant effects but also enhancing the expression of antioxidant enzymes like SOD and ceruloplasmin. [4]
Furthermore, the peptides were proposed to interfere with oxidation chains by interacting with various reactive oxygen species (ROS) through binding with transition metals, thereby bolstering the antioxidant defense system and potentially conferring gero-protective properties.
Possible Therapeutic Capabilities
Research into N-Acetyl Epitalon Amidate suggests a range of potential therapeutic capabilities, primarily based on preclinical studies and in vitro experiments. The peptide has demonstrated intriguing effects in various experimental models. Here are some of the potential therapeutic capabilities identified through scientific investigation:
Anti-Aging Properties: N-Acetyl Epitalon Amidate has attracted attention for its purported anti-aging effects, particularly its ability to modulate telomerase activity. Telomerase plays a crucial role in maintaining the length of telomeres, protective structures at the ends of chromosomes. By enhancing telomerase activity, the peptide may help to preserve telomere length and delay cellular aging processes.
Antioxidant Activity: Studies have suggested that N-Acetyl Epitalon Amidate possesses antioxidant properties, enabling it to scavenge free radicals and reduce oxidative stress within cells. Oxidative stress is implicated in various age-related diseases and degenerative processes. The peptide’s ability to counteract oxidative damage may have implications for combating age-related disorders and promoting cellular health.
Neuroprotective Effects: Preclinical research has indicated potential neuroprotective effects of N-Acetyl Epitalon Amidate. Experimental studies in animal models have suggested that the peptide may mitigate neuronal damage and improve cognitive function. These findings raise the possibility of its utility in neurodegenerative conditions and age-related cognitive decline.
Immune Modulation: Some studies have explored the immunomodulatory properties of N-Acetyl Epitalon Amidate. Research suggests that the peptide may exert regulatory effects on immune cell function and cytokine production. These immunomodulatory effects could have implications for immune-related disorders and inflammatory conditions.
Hormonal Regulation: Preliminary evidence indicates that N-Acetyl Epitalon Amidate may influence hormone secretion and regulation. Studies have suggested potential interactions with hormones such as melatonin and cortisol, which play key roles in circadian rhythms and stress responses. Further investigation is needed to elucidate the mechanisms underlying these hormonal effects and their therapeutic relevance.
Further research, including well-designed clinical trials, is necessary to evaluate its safety, efficacy, and potential utility in therapeutic interventions. Until conclusive data are available, the therapeutic implications of N-Acetyl Epitalon Amidate remain speculative and warrant careful consideration within the scientific community.
Peptides, Research Chemicals & More at Paradigm Peptides
If you are looking to improve your aging research, here at Paradigm Peptides, we carry high-quality N-Acetyl Epitalon Amidate 50mg vials. Learn more about our anti-aging peptides, SARMS, and research chemicals when you reach out to us today.
*Disclaimer: The N-Acetyl Epitalon Amidate currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such.
Research:
[1] https://pubmed.ncbi.nlm.nih.gov/12937682/
[2] https://pubmed.ncbi.nlm.nih.gov/12374906/
[3] https://pubmed.ncbi.nlm.nih.gov/20731122/
[4] https://www.sciencedirect.com/science/article/abs/pii/S0167494307000301?via%3Dihub
| Weight | .25 oz |
|---|---|
| Dimensions | 1 × 1 × 1 in |
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