Buy Hexarelin 2MG Dosage Peptide

In the research provided on hexarelin, most lists it by its other name examorelin. The two are one in the same. Hexarelin works by inducing growth hormone secretion from the pituitary gland.  One of its less known effects according to research is its ability to strengthen neural function.

Application:	Positively affects growth hormone production in the body.
CAS:	140703-51-1
Molecular Weight:	887.04 g·mol
Chemical Formula:	C47H58N12O6
Chemical Name:	L-Histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
Synonyms:	Hexarelin Acetate, Examorelin
Storage:	Minimize open air exposure, store in a cool dry place.
Stability:	2 years
Purity:	98.0%
Solubility:	Soluble to water at rate of 0.1mg/mL
Physical Form:	fine powder in glass vial
Specifications:	2mg vial
Terms:	The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

Hexarelin is a synthetic peptide that belongs to the class of growth hormone-releasing peptides (GHRPs).It is composed of a series of amino acids, which classifies it as a small peptide. It is known for its ability to stimulate the release of growth hormone (GH) from the pituitary gland in the brain.

Structure of Hexarelin

Hexarelin, a synthetic hexapeptide, embodies a structured arrangement of amino acids essential for its biological activity. Comprised of six amino acids, its sequence intricately influences its pharmacological properties and interactions within biological systems. The specific sequence of hexarelin, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, delineates its molecular identity and functional characteristics.

• Histidine (His), positioned at the N-terminus, serves as a pivotal residue for receptor binding and signal initiation. Through its imidazole side chain, histidine facilitates hydrogen bonding interactions crucial for ligand-receptor recognition. This initial interaction sets the stage for subsequent intracellular events.
• The incorporation of D-2-methyltryptophan (D-2-methyl-Trp) confers structural stability and conformational specificity to hexarelin. This modified tryptophan derivative enhances peptide rigidity and receptor selectivity, optimizing its binding affinity and biological potency.
• Alanine (Ala), a nonpolar amino acid, contributes to the hydrophobic core of hexarelin’s structure. Positioned strategically within the sequence, alanine fosters compact folding and hydrophobic interactions critical for peptide stability and receptor recognition.
• Tryptophan (Trp), occurring twice within hexarelin’s sequence, plays multifaceted roles in ligand-receptor interactions and signal transduction pathways. As an aromatic amino acid, tryptophan engages in π-π stacking interactions with aromatic residues within the receptor binding pocket, fostering high-affinity binding and receptor activation.
• D-Phenylalanine (D-Phe), another aromatic residue, augments the hydrophobicity and structural integrity of hexarelin. Its incorporation enhances peptide stability and receptor affinity, augmenting the overall efficacy of hexarelin-mediated signaling cascades.
• Lysine (Lys), located at the C-terminus, serves as a crucial anchor for peptide-receptor interactions. Through its positively charged side chain, lysine engages in electrostatic interactions with negatively charged residues within the receptor binding site, stabilizing the ligand-receptor complex and facilitating downstream signaling events.
• The C-terminal amine group (NH2) represents the terminus of hexarelin, completing its molecular structure. This amine moiety contributes to peptide solubility and stability, ensuring optimal bioavailability and pharmacokinetic properties.

In summary, hexarelin’s molecular architecture epitomizes a finely tuned arrangement of amino acids, orchestrated to elicit precise biological responses. Through its intricate structural composition, hexarelin exemplifies a paradigm of peptide design and engineering, offering insights into the rational design of therapeutically relevant peptides with enhanced efficacy and specificity.

Mechanism of Action of Hexarelin

Hexarelin operates through a well-defined mechanism of action, primarily interacting with the growth hormone secretagogue receptor (GHS-R1a) located on somatotrophs in the anterior pituitary gland. Research indicates that hexarelin’s binding to GHS-R1a triggers intracellular signaling pathways, including phospholipase C and intracellular calcium mobilization. These pathways lead to the activation of protein kinase C and protein kinase A, ultimately culminating in the release of growth hormone.

Studies have shown that hexarelin-induced growth hormone release is potent and dose-dependent. Moreover, hexarelin demonstrates a higher potency and efficacy compared to other growth hormone-releasing peptides, indicating its specificity and effectiveness in stimulating growth hormone secretion.

The precise mechanism underlying hexarelin’s interaction with GHS-R1a and subsequent activation of growth hormone release provides valuable insights into its pharmacological properties and potential therapeutic applications in various medical contexts.

Hexarelin Use In Treatment Of Streptozotocin-Induced Diabetic Rats

In a pivotal study conducted on rats, the synthetic growth hormone (GH) secretagogue hexarelin was scrutinized for its effects on GH secretion in streptozotocin (STZ)-induced diabetic rats. Diabetic rats showcased significantly diminished pulsatile GH secretion, contributing to elevated levels of free fatty acids (FFAs) and reduced insulin-like growth factor 1 (IGF-1) compared to control rats.

Following a two-week hexarelin treatment regimen, diabetic rats exhibited a notable increase in pulsatile GH secretion, normalizing fasting FFAs levels. However, hexarelin treatment did not fully restore circulating IGF-1 levels, indicating partial recovery. The study underscores hexarelin’s potential to rectify impaired GH secretion in diabetic rats, impacting FFAs levels, albeit not completely restoring IGF-1 levels in circulation. [5]

Hexarelin Protects Rat Cardiomyocytes From Ischemia And Reperfusion Injury

In a rat study, hexarelin, a synthetic growth hormone-releasing peptide, demonstrated remarkable cardioprotective actions against myocardial ischemia/reperfusion (I/R) injury. Male SD rats subjected to induced ischemia received hexarelin, ghrelin, or saline for 7 days. Hexarelin treatment exhibited improved cardiac systolic function, reduced malondialdehyde production, and enhanced cardiomyocyte survival compared to saline.

Notably, the beneficial effects of hexarelin slightly surpassed equimolar ghrelin treatment. Moreover, hexarelin down-regulated IL-1β expression and up-regulated IL-1Ra expression in I/R myocardium, effects neutralized by the GHSR antagonist [D-Lys3]-growth hormone-releasing peptide-6 ([D-Lys3]-GHRP-6). The study elucidates hexarelin’s partial protection of cardiomyocytes from I/R injury by modulating the IL-1 signaling pathway via cardiac GHSR1a receptor activation. [6]

Hexarelin Treatment Of MKR Mice To Test Lipid Metabolic Aberrations

In an intriguing mouse study, hexarelin, a growth hormone (GH) secretagogue, exhibited promising effects on fat metabolism in non-obese insulin-resistant MKR mice. These mice received twice daily intraperitoneal injections of hexarelin for 12 days. Hexarelin treatment significantly ameliorated glucose and insulin intolerance while reducing plasma and liver triglycerides in MKR mice.

Enhanced lipid metabolism and adipocyte differentiation in white adipose tissue were attributed to the improved metabolic effects of hexarelin. Despite increased food intake, hexarelin-treated MKR mice maintained stable total body weight, demonstrating corrected abnormal body composition with reduced fat mass and increased lean mass. The study advocates for the potential application of hexarelin in treating lipid disorders associated with the metabolic syndrome. [7]

Therapeutic Implications of Hexarelin

Hexarelin, a peptide known for its ability to stimulate growth hormone release, offers promising therapeutic implications across various medical domains. While its applications extend beyond human contexts, its pharmacological properties suggest potential avenues for therapeutic exploration in preclinical and experimental settings.

Regenerative Medicine and Tissue Repair

Hexarelin’s capacity to enhance growth hormone secretion presents opportunities in regenerative medicine. Research indicates its potential to expedite wound healing processes and facilitate tissue regeneration, particularly in musculoskeletal injuries such as tendon or ligament damage. Preclinical studies highlight its utility in orthopedic rehabilitation strategies.

Neuroprotection and Neurological Disorders

In preclinical models of neurodegenerative diseases, hexarelin demonstrates neuroprotective effects. By modulating growth hormone release and influencing neuronal survival pathways, it holds promise in mitigating neuronal damage and promoting neural repair following injury or disease insults.

Metabolic Homeostasis and Disorders

Hexarelin’s role in regulating growth hormone secretion implicates its potential in metabolic disorders. Animal studies suggest its ability to modulate glucose metabolism, lipid profiles, and energy expenditure. This paves the way for investigating therapeutic interventions for conditions such as obesity and diabetes.

Bone Metabolism and Osteoporosis

Hexarelin’s effects on bone metabolism and mineralization underscore its relevance in bone-related disorders. By stimulating growth hormone release, it may promote osteoblastic activity and enhance bone formation, potentially improving bone density and strength.

While further research is warranted to delineate hexarelin’s full therapeutic scope, its pharmacological profile and mechanisms of action offer exciting avenues for exploration across diverse medical disciplines, from regenerative medicine to metabolic and neurological disorders.

 

*Disclaimer: The Hexarelin currently listed on this site is for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease. It is not intended for human consumption, and is for research purposes only.

Research:

[1] https://pubchem.ncbi.nlm.nih.gov/compound/6918297

[2] https://academic.oup.com/jcem/article-abstract/78/3/693/2651002?redirectedFrom=fulltext

[3] https://link.springer.com/article/10.1007%2FBF00191904

[4] https://academic.oup.com/jcem/article/81/12/4338/2650623

[5] https://www.mdpi.com/1422-0067/19/10/3067

[6] https://www.jstage.jst.go.jp/article/ihj/58/2/58_16-241/_article/-char/ja/

[7] https://academic.oup.com/endo/article/158/10/3174/3964576