Buy GHRP-2 5MG Dosage

For the purpose of research, GHRP-2 has had many names including pralmorelin, KP-102 D, KP 102 LN, and so many more. In research reports, GHRP-2 is commonly tested for its uses as a growth hormone releasing peptide. It’s primary action is through its ability to be an analogue of met enkephalin. In its most basic form, GHRP-2 acts as a ghrelin and growth hormone receptor agonist allowing growth hormone secretion to increase.

Application:	Synthetic growth hormone stimulator
CAS:	158861-67-7
Molecular Weight:	746.90 g·mol
Chemical Formula:	C42H50N8O5
Chemical Name:	D-Alanyl-3-(naphthalen-2-yl)-D-alanyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
Synonyms:	Pralmorelin, growth hormone-releasing peptide 2, GPA 748, KP-102 D, KP 102 LN, GPA-748, WAY-GPA-748
Storage:	Minimize open air exposure, store in a cool dry place.
Stability:	2 years
Purity:	98%
Solubility:	Soluble to water at rate of 0.1mg/mL
Physical Form:	fine powder in glass vial
Specifications:	5mg vial
Terms:	The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic peptide belonging to a class of compounds known as growth hormone secretagogues. These peptides stimulate the secretion of growth hormone (GH) from the pituitary gland in the brain. GHRP-2 is structurally similar to ghrelin, a natural peptide found in the gastrointestinal tract, which also stimulates GH release. GHRP-2 has gained attention for its potential therapeutic applications, particularly in the fields of endocrinology, sports medicine, and aging research.

Structure of GHRP-2

GHRP-2 is a small peptide composed of six amino acids: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. Its chemical structure is designed to mimic the action of ghrelin, specifically targeting the ghrelin receptor (also known as the growth hormone secretagogue receptor or GHS-R1a) in the pituitary gland. This interaction triggers a cascade of signaling events within the cells of the pituitary gland, ultimately leading to the release of growth hormone into the bloodstream.

Mechanism of Action of GHRP-2

The mechanism of action underlying GHRP-2 peptide operation involves intricate interactions with the ghrelin receptor, orchestrating a cascade of intracellular signaling events pivotal in growth hormone secretion regulation. Below delineates the salient steps implicated:

• Binding to the Ghrelin Receptor: GHRP-2 selectively binds to the ghrelin receptor, notably GHS-R1a, localized on the surface of somatotrophs residing in the anterior pituitary gland, the epicenter of growth hormone synthesis and release.
• Activation of Intracellular Signaling Pathways: Upon receptor engagement, GHRP-2 elicits activation of diverse intracellular signaling cascades, notably the phospholipase C (PLC) pathway and the protein kinase C (PKC) pathway. These intracellular signaling networks orchestrate subsequent physiological responses pivotal in growth hormone release regulation.
• Elevation in Intracellular Calcium Levels: GHRP-2-induced receptor activation culminates in the liberation of calcium ions (Ca2+) from intracellular stores within somatotrophs, triggering a sequence of orchestrated events within the cellular milieu.
• Facilitation of Growth Hormone Secretion: Heightened intracellular calcium concentrations instigate the exocytosis of vesicles housing stored growth hormone, facilitating its discharge into the circulatory system. Subsequent to release, growth hormone traverses physiological milieus, exerting its myriad effects on metabolism, tissue regeneration, and various biological processes.
• Secondary Effects: Beyond its primary role in growth hormone secretion modulation, GHRP-2 may engender secondary effects via intricate interactions with alternate receptors and signaling pathways. Putative outcomes encompass augmented appetite, modulation of energy metabolism, and potential neuroprotective attributes, albeit necessitating further elucidation.

In essence, the mechanistic underpinnings of GHRP-2 operation underscore its intricate orchestration of cellular events culminating in growth hormone secretion modulation, thereby advancing scientific understanding in the domain of endocrine physiology and signaling pathways..

Anti-Inflammatory Effect Of GHRP-2 In Rat Model

A study conducted on rats with chronic arthritis induced by Freund’s adjuvant injection, sheds light on the therapeutic potential of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2). Over an 8-day period, arthritic and control rats received either GHRP-2 or saline. Arthritis induction resulted in increased serum ghrelin and decreased leptin levels, yet GHRP-2 administration successfully elevated leptin levels. [3]

Despite its notable increase in food intake among control rats, GHRP-2 exhibited significant benefits in ameliorating external arthritis symptoms in arthritic rats, leading to reductions in arthritis score and paw volume. Moreover, GHRP-2 treatment demonstrated a decrease in IL-6 levels in serum and inhibited endotoxin-induced IL-6 and nitrite/nitrate release from peritoneal macrophages in vitro. These findings underscore the anti-inflammatory effects of GHRP-2 in arthritic rats, hinting at potential clinical implications for immunotherapy. [3]

GHRP-2 On Growth Retardation Study In Yaks

Conducted on yaks afflicted with growth retardation, this study aimed to elucidate the effects of growth hormone-releasing peptide-2 (GHRP-2) and cysteamine (CS) administration on growth performance. Correlations between body weight and serum GHRH, GH, and IGF-1 were significantly noted in yaks with lighter body weights. [5]

In experimental groups, both GHRP-2 and CS administration yielded substantial increases in average daily gain, myofiber diameter, and skeletal muscle area. GHRP-2 notably enhanced serum GH and IGF-1 levels and up-regulated relevant mRNA expression in the liver and skeletal muscle, whereas CS reduced somatostatin levels and down-regulated muscle atrophy-related genes. The study concludes that growth retardation in yaks primarily stems from somatotropic axis hormone secretion deficiency, with GHRP-2 and CS administration offering promising avenues for accelerating growth performance through distinct regulatory mechanisms. [5]

GHRP-2 Produces Antinociceptive Effects In Mice Model Study

In a compelling study conducted on mice, the synthetic agonist of the ghrelin receptor, GHRP-2, was scrutinized for its effects on pain modulation at the supraspinal level using the tail immersion test. Intracerebroventricular administration of GHRP-2 yielded a concentration- and time-related antinociceptive effect, mediated through the activation of GHS-R1α. [6]

Remarkably, the analgesic response elicited by GHRP-2 involved δ- and κ-opioid receptors, as evidenced by the blocking effect of naloxone, naltrindole, and nor-binaltorphimine. Furthermore, GHRP-2 potentiated the analgesic effect induced by morphine, indicating a potential interaction between the ghrelin system and opioids in pain modulation. The study posits GHRP-2 as a promising candidate for the development of new analgesic drugs, opening avenues for further research in pain management. [6]

Therapeutic Implications of GHRP-2 Peptide

GHRP-2 peptide demonstrates therapeutic potential across various scientific domains, primarily evident in preclinical research and animal models.

Investigative Tool in Preclinical Research

GHRP-2 serves as a valuable tool in preclinical investigations, aiding researchers in deciphering intricate pathways related to growth hormone regulation, metabolic dynamics, and endocrine functions. Its utilization in animal models allows for in-depth exploration into the mechanisms underlying growth-related disorders, metabolic aberrations, and age-associated changes. Such insights furnish a foundation for delineating potential therapeutic interventions and management modalities.

Exploration of Growth-Related Disorders

By modulating growth hormone secretion and metabolic processes, GHRP-2 holds promise for unraveling the pathophysiology of growth-related ailments in experimental models. Its application enables researchers to elucidate the mechanisms contributing to conditions characterized by aberrant growth, thereby facilitating the development of targeted therapeutic strategies to ameliorate these disorders.

Potential for Therapeutic Interventions

In the realm of veterinary medicine, GHRP-2 emerges as a prospective candidate for enhancing animal health and welfare. Through its ability to promote growth, augment muscle development, and regulate metabolism, GHRP-2 may offer therapeutic avenues for addressing conditions such as muscle wasting disorders, metabolic irregularities, and growth deficiencies across diverse animal species.

In essence, the therapeutic ramifications of GHRP-2 peptide underscore its multifaceted utility as a research tool and a prospective therapeutic agent, warranting continued exploration and meticulous evaluation across diverse scientific disciplines.

Research Supplies You Can Rely On

At Paradigm Peptides, we carry a wide variety of high-quality, pharmaceutical grade research supplies, including GHRP-2. If you’re in need of GHRP-2 for your next clinical study, we would be happy to help you meet your research requirements. For more information, contact us today.

*Disclaimer: The GHRP-2 currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease. It is not intended for human consumption, and is for research purposes only.

Research:

[1] https://pubchem.ncbi.nlm.nih.gov/compound/6852372

[2] https://link.springer.com/article/10.2165%2F00126839-200405040-00011

[3] https://journals.physiology.org/doi/full/10.1152/ajpendo.00196.2004

[4] https://www.sciencedirect.com/science/article/abs/pii/S0196978197000168

[5] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149461

[6] https://www.sciencedirect.com/science/article/abs/pii/S0196978114000576