Buy GHK-CU Copper Peptide Serum | 50MG

Paradigm Peptides manufactures GHK-Cu for sale at the highest quality and potency available. In most research reports, GHK-Cu is responsible for the stimulation of blood vessels and nerve outgrowth. More recent research has noted that GHK-Cu is also able to protect skin cells from harmful UV rays as well as reduce inflammation.

Application:	Stimulator of blood vessels and nerve outgrowth
CAS:	89030-95-5
Molecular Weight:	403.9242 g·mol
Chemical Formula:	C14H22CuN6O4
Chemical Name:	6-Amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
Synonyms:	Glycyl-L-Histidyl-L-Lysine; Growth-modulating peptide; Kollaren; Liver cell growth factor; Liver growth factor Cu-GHK; Glycyl-histidyl-lysine, monocopper salt
Storage:	Minimize open air exposure, store in a cool dry place.
Stability:	2 years
Purity:	>98%
Solubility:	Soluble to water at rate of 130.98mg/mL
Physical Form:	fine blue powder in glass vial
Specifications:	50mg vial
Terms:	The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

GHK-Cu, also known as Copper Tripeptide-1, is a small naturally occurring peptide composed of three amino acids: glycyl-histidyl-lysine, with a copper ion bound to it. It is found naturally in the human body and has garnered significant attention in skincare and wound healing due to its various biological activities.

Structure of GHK-Cu

GHK-Cu has a simple structure consisting of three amino acids—glycine (Gly), histidine (His), and lysine (Lys)—bound to a copper ion. Its chemical structure can be represented as Gly-His-Lys-Cu. This peptide is water-soluble, which allows it to be easily absorbed into the skin.

Mechanism of Action of GHK-Cu

The mechanism of action of GHK-Cu peptide underscores its multifaceted role in biological systems, particularly in skin physiology and cellular processes. Some of the key mechanisms by which GHK-Cu operates include:

• Antioxidant Properties: GHK-Cu serves as an effective antioxidant agent, mitigating oxidative stress by intercepting and neutralizing harmful free radicals. This function aids in safeguarding cellular integrity and protecting against oxidative damage, which is crucial for maintaining skin health and vitality.
• Wound Healing: GHK-Cu facilitates the intricate process of wound healing by orchestrating various cellular events. It promotes the migration of skin cells to the site of injury, fosters the formation of new blood vessels (angiogenesis), and bolsters the synthesis of extracellular matrix components. These concerted actions expedite tissue repair and regeneration, potentially minimizing scarring and optimizing healing outcomes.
• Anti-inflammatory Effects: GHK-Cu exerts anti-inflammatory effects that contribute to the mitigation of skin inflammation and associated discomfort. By modulating inflammatory pathways, GHK-Cu helps alleviate symptoms such as redness, swelling, and irritation, fostering a conducive environment for skin health and function.
• Copper Homeostasis: Copper plays a pivotal role in numerous physiological processes, including collagen synthesis, antioxidant defense mechanisms, and energy metabolism. GHK-Cu facilitates the maintenance of copper homeostasis within biological systems, ensuring optimal levels of this essential micronutrient for skin integrity, resilience, and functionality.

GHK-Cu Copper Peptide and the Nervous System

GHK-Cu, or Copper Tripeptide-1, presents intriguing prospects for its potential influence on nervous system function, though this area of research remains in its nascent stages. The nervous system, encompassing the brain, spinal cord, and peripheral nerves, orchestrates vital bodily functions, processes sensory inputs, and governs responses to internal and external stimuli.

Neuroprotective Effects

Initial studies hint at GHK-Cu’s neuroprotective capabilities, suggesting its ability to shield nerve cells from degeneration and damage. Neurodegenerative conditions like Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) involve the progressive loss of nerve cells and associated functions. GHK-Cu’s antioxidative traits and its capacity to modulate cellular signaling pathways pose promise for potential neuroprotective effects, albeit necessitating further exploration to elucidate underlying mechanisms.

Enhancement of Neuronal Regeneration

Another avenue of interest pertains to GHK-Cu’s potential to foster neuronal regeneration and repair. Trauma or disease-induced injuries to the nervous system often lead to constrained regenerative capabilities. GHK-Cu’s aptitude for stimulating growth factor production and extracellular matrix synthesis could foster an environment conducive to neuronal regeneration and recuperation, potentially facilitating recovery from nerve injuries and neurodegenerative ailments.

Modulation of Neurotransmitter Activity

Neurotransmitters, pivotal for inter-neuronal communication, maintain neurological equilibrium. Imbalances in neurotransmitter levels or signaling pathways correlate with various neurological disorders like depression, anxiety, and schizophrenia. While investigations into GHK-Cu’s direct effects on neurotransmitter activity remain scant, its knack for modulating cellular functions and signaling pathways hints at plausible indirect influences on neurotransmitter systems.

Copper Homeostasis in the Brain

Copper, an indispensable trace element, orchestrates diverse physiological processes within the brain, encompassing neurotransmitter synthesis, myelination, and antioxidant defense mechanisms. GHK-Cu’s role in regulating copper homeostasis may indirectly impact nervous system function by ensuring optimal copper levels conducive to neuronal health and functionality.

In essence, GHK-Cu’s exploration within the realm of nervous system function showcases intriguing potential, albeit warranting extensive inquiry to unravel its intricate mechanisms and therapeutic implications in neurological contexts.

GHK-Cu Mitigates LPS-Induced Lung Injury in Mice

This study, conducted on mice, delves into the potential of the tripeptide-copper complex glycyl-l-histidyl-l-lysine-Cu (II) (GHK-Cu) in managing acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). GHK-Cu treatment showcases remarkable protective effects in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro and ALI in mice in vivo. [4]

The treatment modulates reactive oxygen species (ROS) production, enhances superoxide dismutase (SOD) activity, and mitigates TNF-α and IL-6 production by suppressing NF-κB p65 and p38 MAPK signaling pathways. In vivo, GHK-Cu attenuates LPS-induced lung histological alterations and curtails the infiltration of inflammatory cells into the lung parenchyma. These findings propose GHK-Cu as a promising therapeutic avenue for ALI/ARDS by tempering excessive inflammatory responses. [4]

Improved Healing in Rat Model of ACL Reconstruction

In a rat study focusing on anterior cruciate ligament reconstruction (ACLR), researchers explore the potential of GHK-Cu in enhancing graft healing post-operation. Intra-articular injections of GHK-Cu post-operatively for four weeks demonstrate significant benefits. At 6 weeks post-operation, GHK-Cu groups exhibit reduced side-to-side differences in knee laxity, indicating improved graft healing following ACLR in rats. [5]

GHK-Cu Reduces Bleomycin-Induced Lung Fibrosis in Animals

This study investigates the therapeutic efficacy of the tripeptide-copper complex glycyl-L-histidyl-l-lysine (GHK-Cu) in a mouse model of bleomycin (BLM)-induced pulmonary fibrosis. BLM-induced pulmonary fibrosis, characterized by advancing diffuse fibrosis, oxidative stress, and inflammation, is mitigated with intraperitoneal injections of GHK-Cu at various dosages. [6]

GHK-Cu demonstrates a protective effect by inhibiting BLM-induced inflammatory and fibrotic changes, reducing inflammatory cytokines, and ameliorating collagen deposition. Moreover, it reverses MMP-9/TIMP-1 imbalance, partially prevents epithelial-mesenchymal transition (EMT) through Nrf2, NF-κB, and TGFβ1 pathways, and inhibits Smad2/3 phosphorylation. These findings underscore GHK-Cu’s potential in averting BLM-induced inflammation and oxidative stress, impeding EMT progression, and suppressing TGFβ1/Smad2/3 signaling in pulmonary fibrosis. [6]

Research Chemicals at Paradigm Peptides:

At Paradigm Peptides, we carry high-quality GHK Cu 50mg vials, which are designed for research purposes only. Learn more about our tested and authenticated research chemicals when you reach out to us today.

*Disclaimer: The GHK-CU Copper Peptide Serum currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such.

Research:

[1] https://pubchem.ncbi.nlm.nih.gov/compound/342538

[2] https://www.mdpi.com/1422-0067/19/7/1987

[3] https://www.hindawi.com/journals/omcl/2012/324832/

[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295439/

[5] https://onlinelibrary.wiley.com/doi/full/10.1002/jor.22831

[6] https://www.sciencedirect.com/science/article/abs/pii/S0024320519310677

Disclaimer: The GHK-CU Copper Peptide Serum currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such.