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CJC 1295 with DAC 2MG Dosage

$37.00

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Research has placed CJC-1295 with DAC as a growth hormone peptide. It is most commonly used in studies that stimulate growth hormone release from the pituitary gland. Studies have shown that growth hormone is responsible for several important functions within the body.

Application: Synthetic analogue of GHRH
CAS: 863288-34-0
Molecular Weight: 3367.954 g·mol
Chemical Formula: C159H258N46O45
Chemical Name: L-Tyrosyl-D-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-argininamide
Synonyms: Mod GRF(1-29), CJC-1295 W/O DAC. CJC-1295 Acetate
Storage: Minimize open air exposure, store in a cool dry place.
Stability: 2 years
Purity: 99%
Solubility: Soluble to water at rate of 0.1mg/mL
Physical Form: fine powder in glass vial
Specifications: 2mg vial
Terms: The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

CJC 1295 with DAC – What You Should Know

CJC 1295 with DAC is a growth hormone peptide. This means that it helps to stimulate growth hormone release from the pituitary gland. In synthetic form it typically comes as a white crystalline powder and needs to be reconstituted.

What is CJC 1295?

CJC 1295 with DAC was developed by ConjuChem Biotechnologies and the DAC at the end of the peptide is actually an acronym for drug affinity complex. In any sense, CJC 1295 DAC is a synthetic analog of growth hormone-releasing hormone also called growth hormone-releasing factor. This makes it a growth hormone secretagogue. What does that mean? It means that CJC 1295 with DAC aids in the secretion of growth hormone.

It works by increasing IGF 1 as well as plasma growth hormone. Ever heard of the term bioconjugation? This is a chemical strategy that actually forms a stable bond between two molecules. Why is this important? Because CJC 1295 with DAC is able to extend the half-life and bioavailability of growth hormone-releasing hormone 1 – 29 because of this process.

Normalization of Growth in GHRH Knockout Mice

The majority of children with isolated growth hormone (GH) deficiency typically respond well to GH-releasing hormone (GHRH) therapy, but its short half-life limits its effectiveness. In mice lacking the GHRH gene (GHRH knockout; GHRHKO), even twice-daily injections of a GHRH analog fail to normalize growth. CJC-1295, a synthetic GHRH analog, binds to endogenous albumin after injection, extending its half-life and action duration. This study evaluates the effects of CJC-1295 in GHRHKO mice. Three groups of GHRHKO mice were treated for 5 weeks with CJC-1295 at different intervals. 

Daily doses maintained normal body weight and length, while injections every 48 and 72 hours resulted in higher body weight and length but did not fully normalize growth. Femur and tibia length remained normal with injections every 24 and 48 hours, and lean and fat mass were normal across all treatment groups. CJC-1295 increased total pituitary RNA and GH mRNA, suggesting somatotroph cell proliferation, supported by immunohistochemistry images. In conclusion, once-daily CJC-1295 administration maintained normal body composition and growth in GHRHKO mice, but was less effective when given every 48 or 72 hours. [1]

Prolonged Stimulation of Growth Hormone and IGF-I Secretion by CJC-1295

The study investigated the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog. Two randomized, placebo-controlled, double-blind trials were conducted, lasting 28 and 49 days, respectively, involving healthy participants aged 21–61 years. 

CJC-1295 or placebo was administered subcutaneously in various doses and schedules. Main outcomes included peak concentrations and area under the curve of growth hormone (GH) and insulin-like growth factor-I (IGF-I), along with standard pharmacokinetic parameters for CJC-1295. [2]

Following a single injection, CJC-1295 led to dose-dependent increases in plasma GH and IGF-I. The estimated half-life of CJC-1295 ranged from 5.8 to 8.1 days. Multiple doses sustained elevated IGF-I levels above baseline for up to 28 days. No serious adverse reactions were reported, and CJC-1295 was generally well tolerated, especially at doses of 30 or 60 μg/kg. Cumulative effects were observed after multiple doses, indicating the potential utility of CJC-1295 as a therapeutic agent for enhancing GH and IGF-I levels in healthy adults. [2]

CJC 1295 with DAC from Paradigm Peptides

All of our products are pharmaceutical grade and are manufactured right here in the Midwest. Each product undergoes stringent testing to ensure the absolute best products. Have questions about ordering or the products you’re looking at? Our friendly customer service team is here to help.

Research:

[1] https://pubmed.ncbi.nlm.nih.gov/16822960/

[2] https://academic.oup.com/jcem/article/91/3/799/2843281?login=true

[3] https://academic.oup.com/jcem/article/91/12/4792/2656274?login=true

Disclaimer: The CJC-1295 with DAC currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease. It is not intended for human consumption, and is for research purposes only.

Weight .25 oz
Dimensions 1 × 1 × 1 in
Weight

7 grams or .3 oz

Dimension

2"H x 1"W x 1"L