BPC-157 5 mg

High-Quality BPC-157 For Sale From Paradigm Peptides

Paradigm Peptides manufactures BPC-157 for sale at the highest quality and potency available. The BPC-157 peptide, referred to as pentadecapeptide in various research articles, is a synthetic peptide. In animal research studies, BPC-157 was proven to aid wound healing and certain bowel disorders.

One such study included research on spinal injuries in rats. The rats treated with BPC-157 showed an improvement in motor functions proving that the BPC-157 peptide can aid in faster wound healing.

The BPC-157 peptide for sale on this site is for research purposes only and not for human consumption.

Application:	Aids in wound healing
CAS:	137525-51-0
Molecular Weight:	1419.53552 g·mol
Chemical Formula:	C62H98N16O22
Chemical Name:	Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Synonyms:	Pentadecapeptide BPC-157, PL 14736
Storage:	Minimize open air exposure, store in a cool dry place.
Stability:	2 Years
Purity:	99%
Solubility:	Soluble to water at rate of 0.1mg/mL
Organoleptic Profile:	Powder
Physical Form:	Crystalline powder
Specifications:	5mg
Container:	5mg vial
Terms:	The products we offer are intended for laboratory research use only. You will need to purchase Bacteriostatic water separately.

In many research situations, a BPC-157 injection is administered during the third step of the healing process. This is because new connective tissues and tendon fibroblast are sped up once taken, making everything go by faster.

BPC 157 Molecule

BPC-157, also known as Body Protection Compound-157, is a synthetic peptide composed of 15 amino acids. It has gained attention for its potential therapeutic properties, particularly in promoting healing and tissue repair.

Structure

BPC-157 is a peptide derived from a protein found in the stomach called Body Protection Compound. It consists of a sequence of 15 amino acids: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. Known for its stability in gastric juice, BPC-157 exhibits subcutaneous bioavailability, offering significant advantages for therapeutic applications.

Stability in Gastric Juice

One of the remarkable characteristics of BPC-157 is its stability in gastric juice. Gastric juice is highly acidic and contains various enzymes that can degrade proteins and peptides. However, BPC-157 remains intact and stable even in the acidic environment of the stomach. This stability allows BPC-157 to survive the harsh conditions of the digestive system.

Oral Bioavailability

The stability of BPC-157 in gastric juice contributes to its oral bioavailability. Oral bioavailability refers to the fraction of an administered dose of a substance that reaches the systemic circulation and is available for distribution to target tissues. In the case of BPC-157, its ability to withstand degradation in the stomach allows it to be absorbed intact into the bloodstream after oral administration. This is a significant advantage for therapeutic applications, as it eliminates the need for invasive routes of administration, such as injections.

Mechanism of Action

The exact mechanism of how BPC-157 works is not fully understood, but research suggests several potential mechanisms:

• Modulation of Growth Factors: BPC-157 may exert its effects on tissue repair by modulating the activity of various growth factors involved in the healing process. For example, it has been shown to upregulate the expression of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), among others. FGF and VEGF are key regulators of cell proliferation, migration, and differentiation, as well as angiogenesis. By enhancing the activity of these growth factors, BPC-157 promotes the recruitment of cells involved in tissue repair and stimulates the formation of new blood vessels, ultimately accelerating the healing process.
• Anti-inflammatory Effects: Inflammation is a natural response to tissue injury and is essential for initiating the healing process. However, excessive or prolonged inflammation can delay healing and contribute to tissue damage. BPC-157 exhibits anti-inflammatory properties by inhibiting the activity of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Additionally, it promotes the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10). By modulating the balance between pro-inflammatory and anti-inflammatory signals, BPC-157 helps reduce inflammation at the site of injury, allowing the healing process to proceed more efficiently.
• Protection Against Oxidative Stress: Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses. ROS can cause damage to cellular components, including proteins, lipids, and DNA, leading to tissue injury and impaired healing. BPC-157 has been shown to protect cells from oxidative stress-induced damage by scavenging free radicals and enhancing antioxidant defenses. It upregulates the expression of antioxidant enzymes, such as superoxide dismutase (SOD) and catalase, which help neutralize ROS and prevent oxidative damage. By mitigating oxidative stress, BPC-157 supports tissue recovery and regeneration, particularly in conditions associated with inflammation and tissue injury.

Cell Running & BPC-157

Cell running refers to the phenomenon wherein blood vessels extend and grow towards the vicinity of an injury. This biological process, also known as angiogenesis, plays a crucial role in wound healing and tissue repair. When tissue damage occurs, the body initiates a series of complex signaling pathways to stimulate the formation of new blood vessels, ensuring the delivery of oxygen, nutrients, and immune cells to the injured site. Angiogenesis facilitates the restoration of tissue function and promotes overall healing.

In the context of BPC-157, this peptide has shown a notable correlation with the process of cell running. When administered through injections by research specialists, BPC-157 appears to enhance and facilitate angiogenesis, thereby promoting the migration and growth of blood vessels towards the injured area. This phenomenon is significant in the context of tissue repair, as it helps establish an effective network of blood vessels that support cellular functions and contribute to the healing process.

The correlation between BPC-157 injections and cell running underscores the peptide’s potential therapeutic benefits in promoting efficient wound healing and tissue regeneration. By facilitating angiogenesis, BPC-157 may enhance the body’s natural healing mechanisms, leading to accelerated recovery and improved outcomes in various injury and disease conditions.

Further research is necessary to fully elucidate the mechanisms underlying the relationship between BPC-157 and cell running and to explore its clinical implications in various medical contexts. Nonetheless, the observed correlation highlights BPC-157 as a promising candidate for therapeutic interventions aimed at enhancing tissue repair and regeneration.

Investigating BPC-157’s Role in Catalepsy & Gastric Ulcers: Rodent Models

Recent research delves into the multifaceted effects of the gastric pentadecapeptide BPC 157, renowned for its protective capabilities in the gastrointestinal tract and beyond. Notably, studies have illuminated its influence on dopamine systems, particularly in mitigating stereotypy induced by amphetamine in rats and haloperidol-induced supersensitivity to amphetamine in mice. This investigation aims to elucidate whether BPC 157 can mitigate the immediate effects of neuroleptics, notably catalepsy.

In mouse experiments featuring haloperidol and fluphenazine, the co-administration of BPC 157 exhibited significant reductions in catalepsy, delaying its onset and diminishing the number of cataleptic mice. Moreover, the peptide demonstrated efficacy in reducing somatosensory disorientation among challenged mice. [1]

In parallel rat experiments, BPC 157 displayed inhibitory effects on gastric ulcers induced by haloperidol, suggesting its protective role within the gastric system. Collectively, these findings underscore BPC 157’s interaction with the dopamine system, both centrally and peripherally, thereby potentially interfering with catalepsy and/or ulcer formation pathways. [1]

Inflammatory Bowel Disease Treatment: BPC-157 Rat Studies

Exploring the therapeutic potential of the gastric pentadecapeptide BPC 157, this study sheds light on its cytoprotective and adaptive cytoprotective properties. Notably safe in clinical trials for inflammatory bowel disease, BPC 157 emerges as a stable and versatile peptide with profound effects.

The research elucidates BPC 157’s ability to maintain mucosal integrity amidst stomach distension, thereby preventing lesions in gastric, esophageal, and duodenal regions. When instilled into the stomach, BPC 157 preserves consistent blood vessel presentation and inhibits lesions, surpassing the partial effects of conventional agents such as atropine, ranitidine, and omeprazole. [2]

Furthermore, the study underscores BPC 157’s myriad impacts on the gastrointestinal tract, including its modulation of the NO-system, somatosensory neurons, salivary glands function, and AMP-ADP-ATP system recovery. Additionally, BPC 157 demonstrates promise in counteracting alcohol effects, addressing central dopamine system disturbances, and inducing serotonin release in the substantia nigra, thus offering therapeutic potential in wound healing and sphincter pressure recovery during stomach distension. [2]

Ligament Healing In Animal Models

In pursuit of enhanced medial collateral ligament (MCL) healing, this study investigates the efficacy of stable gastric pentadecapeptide BPC 157 in a rat model over a 90-day period post-surgical transection. Known for its anti-ulcer properties and effectiveness in inflammatory bowel disease therapy, BPC 157 is administered through various routes—intraperitoneally, per-orally (in drinking water), and topically (via thin cream layer)—without a carrier.

The results demonstrate BPC 157’s efficacy in improving MCL healing across different administration methods. Rats treated with BPC 157 exhibit consistent functional, biomechanical, macroscopic, and histological improvements, suggesting its potential as a contributor to enhanced healing in acute ligament injuries within the realm of ligament therapy. [3]

Therapeutic Implications

The subcutaneous administration of BPC-157 offers an effective alternative for therapeutic use. Unlike oral administration, subcutaneous injections ensure direct delivery of BPC-157 into the bloodstream, potentially enhancing its therapeutic efficacy. This method bypasses the digestive system, allowing for more predictable absorption and distribution to target tissues.

BPC-157 has showcased promising therapeutic benefits in numerous preclinical and clinical investigations, including:

• Musculoskeletal Healing: BPC-157 has shown promise in accelerating the healing process of various musculoskeletal tissues, including tendons, ligaments, muscles, and bones. It promotes tissue repair by stimulating angiogenesis (formation of new blood vessels), collagen synthesis, and fibroblast proliferation. These mechanisms help improve blood flow to the injured area, enhance the deposition of collagen, and accelerate the regeneration of damaged tissues.
• Gastrointestinal Healing: BPC-157 exhibits gastroprotective properties and has been investigated for its therapeutic potential in various gastrointestinal disorders. It has shown efficacy in protecting the gastrointestinal mucosa from injury and promoting the healing of gastric ulcers and other types of gastrointestinal lesions. Additionally, BPC-157 has demonstrated anti-inflammatory effects in the gastrointestinal tract, making it a potential treatment option for inflammatory bowel disease (IBD) and other inflammatory conditions. Its ability to enhance mucosal integrity and reduce gut permeability suggests that it could also be beneficial in conditions associated with leaky gut syndrome.
• Wound Healing: BPC-157 has been shown to promote the healing of wounds and skin injuries through multiple mechanisms. It enhances tissue regeneration by stimulating the proliferation and migration of fibroblasts, which are responsible for producing collagen and extracellular matrix components essential for wound closure. Additionally, BPC-157 stimulates angiogenesis, facilitating the formation of new blood vessels that supply oxygen and nutrients to the wound site. By accelerating the formation of granulation tissue and promoting collagen synthesis, BPC-157 helps expedite the healing process and may improve the overall quality of tissue repair.
• Neurological Conditions: Emerging research suggests that BPC-157 may have neuroprotective effects and could hold therapeutic potential for various neurological disorders. It has been investigated in preclinical studies for its ability to mitigate neuronal damage and improve functional recovery following traumatic brain injury (TBI), stroke, and other neurological insults. BPC-157’s mechanisms of action in the central nervous system include reducing inflammation, promoting neuronal survival, and modulating neurotransmitter systems. While further research is needed to elucidate its precise effects and therapeutic applications in neurological conditions, BPC-157 represents a promising avenue for neuroprotection and neuroregeneration.

Buy BPC-157 For Sale At Paradigm Peptides

If you’re interested in finding BPC-157 for sale online, look no further than Paradigm Peptides. We’re a proud manufacturer of top-quality peptides, nootropics and research chemicals of all types. We only sell American-made BPC-157 manufactured in the Midwest; everything undergoes strict testing protocols before being available. Want to learn more or have some questions about BPC-157? Contact us today. Our friendly customer service team is here to help.

*Disclaimer: The BPC-157 peptide for sale on this site is for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic, and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease.

Research:

[1] https://www.sciencedirect.com/science/article/abs/pii/S0014299999004860?via%3Dihub

[2] https://link.springer.com/article/10.1007%2Fs10787-006-1531-7

[3] https://onlinelibrary.wiley.com/doi/10.1002/jor.21107

[4] https://www.sciencedirect.com/science/article/abs/pii/S0928425797894806

[5] https://www.mdpi.com/2227-9059/9/7/744

[6] https://pubmed.ncbi.nlm.nih.gov/29358856/

[7] https://www.ingentaconnect.com/content/ben/cpd/2020/00000026/00000025/art00005

[8] https://pubmed.ncbi.nlm.nih.gov/29682749/

[9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504390/

[10] https://www.mdpi.com/2079-7737/10/9/891

[11] https://www.mdpi.com/2227-9059/10/11/2696

[12] https://www.sciencedirect.com/science/article/abs/pii/S002432052200772X

High Performance Liquid Chromatography | BPC-157

Mass Spectrometry | BPC-157