Cardarine GW 501516 : Muscle Gain & Maintenance | Paradigm Peptides

After a long hard day at work, hitting the gym is the last thing on your mind. You get home and you just want to hit the pillow and knock out for the rest of the night. Sound familiar? You’re not alone, there are many individuals that are dealing with this. But it can be combated. Then you can get back to getting stacked. How? With the help of Cardarine.

What is Cardarine?

Cardarine is known by many names including GW-501,516; GW1516, GSK-516, and Endurobol. It is a peroxisome proliferator-activated receptor delta which means that it in charge of many different biological processes. This particular compound was being investigated for its abilities to aid in many things including boosting the metabolism, fat burning, and even prevention of obesity.

In 1992, Cardarine was discovered during a research collaboration between GlaxoSmithKline and Ligand Pharmaceuticals. In 2000, GlaxoSmithKline began phase I trials for its use in the treatment of hyperlipidemia. Hyperlipidemia is higher than normal levels of lipids or lipoproteins in the blood. By 2002, it had undergone phase I and II trials. By 2007, GW 501516 has started and completed two phase II studies on GW 501516 and its abilities to treat obesity, diabetes, dyslipidemia, and cardiovascular disease.

Because of higher doses causing cancer to develop in rats and mice, GlaxoSmithKline abandoned all further studies on GW 501516. However, this was not the end of the road for GW 501516. Ronald M. Evan’s Laboratory purchased a sample of the Cardarine compound and gave mice an increased dose which had been significantly higher than the one GlaxoSmithKline had given to their mice. With this higher dose, it was noted that there was a dramatic increase in the physical performance of these mice.

Studies on Cardarine


A cluster of brain cells cultures used in preparation were taken from embryonal rat brain. The exstraction was in order to better understand inflammatory responses triggered by IFN-gamma and lipopolysaccharide (LPS). There was a significant decrease in the IFN-gamma-induced up-regulation of TNF-alpha and iNOS in addition to the anti-inflammatory effects.

Weight Loss & Obesity

Wild type mice were placed on a high fat diet with their food having a fat content of 35% and were then treated using GW 501516 over the course of two months. Within that two months, the mice only gained roughly 30% in body weight. Along with these results, there was a dramatic reduction in fat mass and an improvement in glucose tolerance.

In a second study done with six obese rhesus monkeys from the Obesity and Diabetes Research Center at the University of Maryland. Their diet consisted of 13% fat, 18% protein, and 69% carbohydrates. GW 501516 delivery is twice a day at an initial dose of 0.1mg/kg and a final dose of 3.0mg/kg for the study. The monkeys ate a small “snack” twice a day for administration purposes. At the completion of the study, those that were on the GW 501516 regimen saw a reduction in food consumption.

Heart Health

Over the course of a twelve week study, patients were divided into groups. Each group took GW 501516 dosages of 2.5mg, 5.0mg, or 10mg. Patients took part based on if they were experiencing high-density lipoprotein (HDL) cholesterol level of < 1.16 mmol/L, which is the average for both men and women. At the beginning of the study fasting insulin, glucose, free fatty acids, and lipids were measured for a baseline. The results, GW 501516 produced a significant change in both HDL and LDL cholesterol and it was concluded that GW 501516 can potentially be targeted for providing cardiovascular protection.

Side Effects of Cardarine

Although GW 501516 has been known to speed up cancer development in animal studies, there is not a sufficient amount of evidence with humans to see if that same effect can happen on a human scale.

One other thing to consider is that if you are a woman looking to use Cardarine, and if you are pregnant or expect to become pregnant, it is not for you as it can pose a risk to the development of the fetus.

Benefits of Cardarine

There are countless common benefits to using this compound. For one, you have the ability to improve your stamina. Have you ever got home from work and just been completely drained? So much so that you avoid going to the gym? Get back your energy and hit the gym with the help of Cardarine. Not only does it help stamina, it also helps with endurance giving you the ability to have longer workouts. You can also expect faster fat loss when using it because you’re working it all out of your system. Not looking to slim down. That’s fine too, since Cardarine can also just help maintain the muscle mass you already have.

Cardarine Dosage

When it comes to dosage, this plays a key role for Cardarine. For one, the length of the cycle set at eight weeks. The dose fluctuates a bit. That way you allow for your body to get used to it. For the first week of using GW 501516, the dose is 10mg per day. Once you finish off that first week, you can bump that dose up to 20mg per day for the remaining seven weeks. Like with most SARMs you’ll want to take a break from Cardarine for at least eight weeks after your cycle to give your body time to detox and recover. The nice thing about this particular compound is that, unlike most SARMs, a PCT or post cycle therapy is not necessary.

Stacking Cardarine


If you’re looking for a cutting stack, Ostarine and Cardarine are a great pair. When you combine the two, they complement each other and turn your body into a fat burning machine. The cycle length is like most SARMs stacks and tops out at eight weeks. In terms of dosages, Cardarine follows its basic dose protocol from above in that it starts out the first week at 10mg per day and then for the remaining several weeks bumps up to 20mg per day. Ostarine on the other hand, stays at a steady 20mg per day. The big difference here is that unlike taking just Cardarine, a PCT is necessary for four weeks preceding the stack.

Ostarine + Andarine

If you’re looking for a more advanced stack you can pair Cardarine with Ostarine and Andarine. This stack will give you optimal muscle gains and keep you going while you do. This cycle can vary a bit in length and be as little as eight weeks or as long as ten weeks. Again, Cardarine stays with the same dosage protocol of 10mg per day for the first week and then 20mg for the remainder of the cycle.

Andarine also fluctuates with this stack as it starts out the first week at 25mg and then bumps up to 50mg for the rest of the cycle. Ostarine stays consistent throughout the cycle at 20mg per day. For this cycle as with the one of just Ostarine and Cardarine, a post cycle therapy for four weeks is necessary along with a break period the length of the stack. This means if you’ve completed the stack in eight weeks, you’ll want to give your body eight weeks to return to normal before completing another cycle.

Paradigm Peptides for Bodybuilding

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