27 Jul Cabergoline: Not Your Average PCT
Several products exist on the market for post cycle therapy options. So how do you know what the best option is for your situation. For one, what is the issue your having? Are you having problems with keeping your estrogen and testosterone in balance? No, okay what about your prolactin levels? Bingo, we have a winner. With the help of Cabergoline you can even out your prolactin levels. Thereby, avoid things like gynecomastia while still reaping the benefits of your workouts.
Cabergoline is a research chemical. This specific supplement is an ergot derivative. Meaning that it comes from a group of fungi whose genus is Claviceps. It is a potent dopamine receptor agonist. Specifically, it is an agonist to the D2 receptors. Because of how it works, there is a repressive effect on the pituitary glands lactotroph cells and prolactin secretion.
An Italian drug company known as Farmitalia Carlo Erba was the first to find it. It’s first appearance in the mainstream was in 1980 when the patent got filed.
The Italian company was experimenting with the semisynthetic derivatives of the ergot alkaloids at the time of the discovery. These type of alkaloids are considered to be secondary metabolites. The groups of ergot alkaloids are clavines, lysergic acid, and ergopeptines.
After its discovery in 1980, Cabergoline underwent testing. Then in 1991 a published abstract appeared at the Society of Neuroscience meeting. New developments ensued, as the company that developed this substance was acquired twice by two separate entities.
Right before the acquisitions began, things were happening for this new drug. In the Netherlands during 1992, it was approved under the name Dostinex and marketed. Then in between the acquisitions it was approved by the FDA in December of 1996.
The first occurrence of acquisition occurred in 1993. The Italian company was acquired by a company named Pharmacia. Then in 2003, the second acquisition occurred when a common company known as Pfizer acquired it.
Studies with Cabergoline
Micro- & Macroprolactinoma
For starters, what the heck is macroprolactinoma and macroprolactinoma? Well, macroprolactinoma is a non-cancerous tumor that develops in the pituitary gland. When a tumor is larger than 1cm, the condition is then referred to as macroprolactinoma.
Patients between the ages of 17 and 70 that experience macroprolactinoma took part in this study. The goal was to test the effects of Cabergoline as a treatment option. In addition to these forty one individuals another ten patients between the ages of 18 and 53 also took part. These ten individuals were experiencing microprolactinoma.
The basic goal of the study is to see if prolactin levels, restoration of pituitary function and treatment of tumors is a possibility when using this particular substance. Over the course of twenty four months, the patients underwent treatment. Within this time frame, results were very promising.
Of the patients, 31 of the macroprolactinoma patients saw their prolactin levels normalize. In addition to the normalization of their prolactin, they also saw galactorrhea disappear as well. What is galactorrhea? It’s basically a milky discharge from the nipple that isn’t related to typical milk production in the breast.
Individuals also had their non-cancerous tumors shrink in both groups. Some of the tumors even disappeared altogether. For some of the patients, headaches were a constant. Fifteen of the patients saw headaches dissipate while taking part in the study with Cabergoline. However, one of the most notable outcomes of the experiment was the normalization of testosterone for 31 patients.
For those that may not know, prolactin is a hormone that is produced by the pituitary gland. This is a relatively small but powerful area located in the brain. It is what causes breasts to develop and create milk once a baby is born for women. Whether you are a woman or man, prolactin is present in small amounts in your blood.
This is where a study done with one hundred and forty women becomes important. Cabergoline was tested to determine its dose dependency on prolactin levels. These 14o women were divided into four groups and were either administered various doses of the substance or a placebo. This meant that there were three groups of forty women with the final group having only 20 women. Of those in the testing groups, they were administered doses of 0.5mg, 0.75mg, and 1.0mg.
It is important to note that the women in this study delivered their baby. Then, twelve hours later received the first treatment. After treatment, the women were examined at 6 hours, 12 hours, the first five days and the fourteenth day. The main focus of these examinations was milk secretion, pain, breast engorgement, side effects, and prolactin levels.
The main outcomes for the women involved varied based on dose. The women taking 1.0mg of Cabergoline saw a 90.2% reduction in lactation. Whereas, those taking 0.5mg only saw a 45% reduction.
So, what does any of this have to do with you? For those in the fitness community that use anabolic steroids, “man boobs” or gynecomastia is a thing. Cabergoline can help reduce side effects associated with the use of these substances.
Most Common Benefits
- Treatment in Early Parkinson’s disease patients
- Reduction of prolactin in the blood
- Aids in the treatment of gynecomastia
- Prevents Infertility Issues
Side Effects to Look For
Of course, side effects do exist for Cabergoline. However, they are fairly minimal and, in most situations, extremely mild. The most common include headaches, vomiting, indigestion, light-headedness, nausea, and hot flashes.
Dosage Protocol for Cabergoline
For a single dose, it can take anywhere from thirty minutes to four hours for it to start working. Something to take note of is the ability to take it with or without food. Either method works. If you do decide to take it with food, you don’t have to worry about its absorption by the body.
When it comes to those taking anabolic steroids, having a post cycle therapy regimen ready is the way to go. It is your best option for avoiding the nasty side effects that exist with these substances. Cabergoline is one method you can use to combat these side effects while still enjoying the gains.
Using it as your post cycle therapy regimen, a suggested dosage is 0.25mg twice a week. However, if you are not noticing a difference, you can increase this dose to 0.50mg per dose twice a week. Keep in mind that with upping the dose, you don’t want to exceed 1mg a week. This is the max dose without any real negative side effects to be known.
So, what is a post cycle therapy and why is it important? For many, a post cycle therapy of four weeks is a way to assist the body back to normal levels. It is the most effective way to not lose everything you’ve worked for. This is especially important if you’re noticing things like acne, breast development and other side effects of steroid use.
Does Cabergoline sound like the right fit? Not sure where to get it at top quality without totally breaking the bank? Why not try Paradigm?
Paradigm Peptides for PCTs
So now what? You have all this information but how do you know that Cabergoline is right for you. If the scenario fits your circumstances then it may be right for you. When it comes to buying research chemicals, Paradigm makes it simple. We carry only the highest quality products that are stringently tested to ensure you get only the best. Giving you the information you need at your fingertips is what we do best. Ready to start your PCT journey with us? Then let’s get started!