TB-500: One of the Best Healing Peptides | Paradigm Peptides

You’re running your normal five miles one fall morning when you start to feel it. You can’t tell for sure because of the brisk cool air, but something in your knee doesn’t feel right. You get home, and after a hot shower and a bit of relaxing, you look down to see your knee swollen, and a fair amount of pain starts to radiate through it. What can you do to alleviate your acute pain and reduce the inflammation around your knee? Healing peptides just might do the trick — and one of the best options is TB-500. But before you decide to buy TB-500, we’ll tell you everything you need to know about it and its many benefits.

What Is TB-500?

TB-500 is a synthetic version of a region that is active in Thymosin Beta-4 and occurs naturally in the body. It is commonly considered one of the top peptides for healing tendons and various wounds quicker. Thymosin Beta-4 is essentially the parent peptide of TB-500. Thymosin Beta-4 consists of forty-three amino acids and has a molecular weight of 4,921 g/mol. As healing peptides, Thymosin Beta-4 and TB-500 essentially do the same thing. However, because of Thymosin Beta-4’s size, it is not commonly or easily produced. This makes it easier to manufacture and, therefore, easier to buy TB-500.

How Do TB-500 Healing Peptides Work?

TB-500 works by building new blood vessels and muscle tissue fibers while assisting in new cell migration and blood cell reproduction. It works based on its ability to upregulate cell-building proteins, such as actin. Actin is a protein that forms, in conjunction with myosin, the contractile filaments of muscle cells. It is what allows for a faster healing time and cell growth, migration and proliferation. Once injected, it finds the wounded area and goes to work mending the damaged tissue.

Benefits of TB-500

This synthetic peptide has a long list of benefits and no known side effects, making TB-500 ideal for those seeking muscle gain and quick healing times. TB-500 has been noted as one of the best peptides for healing tendons, ligaments, muscles and skin, and it can even help with eye injuries and heart conditions. Those who have used TB-500 after a heart attack have been shown to have a faster recovery rate.

Not only does it help with these areas, but it also helps to increase strength through muscle growth. Quicker healing times due to TB-500 have also been shown to:

  • Improve endurance
  • Reduce acute and chronic pain, spasms and inflammation
  • Protect and restore neurons after brain injuries
  • Help with hair regrowth
  • Increase flexibility

The TB-500/BPC-157 Stack

Another benefit of this peptide is that TB-500 and BPC-157 stack well with each other. Both are common healing peptides that naturally occur in the body, with BPC-157 occurring in the stomach and intestines. The job of BPC-157 is to heal the intestinal tract and stomach lining. Much like TB-500, it can aid in the healing of wounds in other areas of the body. The TB-500/BPC-157 stack has the benefit of little to no scarring.

Vital Information on Dosage, Reconstitution & Storage of TB-500

When it comes to reconstituting these amazing healing peptides, you should know the ins and outs. In this section, we’ll show you everything you need to know about the dos and don’ts of reconstitution for TB-500.

For example, do you know the temperature at which your TB-500 should be stored? Both the powder form and reconstituted TB-500 should be stored between 36 and 46-degrees Fahrenheit.

If you maintain this temperature (or colder) when storing your vial of unconstituted TB-500, it could last you up to 24 months. If for some reason you cannot store it at this temperature and must keep it at room temperature, which is somewhere right around 68-degrees Fahrenheit, your TB-500 will still be good. However, it will only be good for about 90 days as opposed to 24 months. If you end up storing it at a higher temperature (like over 113-degrees Fahrenheit), it would only be suitable for about a week.

Once reconstituted, TB-500 should be used within eight days — when correctly stored between 36 and 46-degrees Fahrenheit. Ideally, the peptide should not be frozen.

Next on the list of importance is the kind of liquid you use to reconstitute your TB-500 — and how to do so correctly. When it comes to the reconstitution of your TB-500, you want to use one of the following:

  • Plain sterile water
  • Sterile saline
  • Sterile bacteriostatic water

The process of reconstitution for TB-500 is quite easy. It is recommended that you use an insulin type syringe, then follow these steps:

  • To reconstitute your TB-500, pull one milliliter of water into the syringe.
  • Inject the water into your unconstituted TB-500.
  • Do not force the liquid into the vial, as that can render it completely useless.
  • Instead of forcing the liquid into the vial, slowly inject the liquid, letting it slide down the side of the vial.

As for the dosage, that purely depends on the severity of the injury or what you are using healing peptides to treat. Most of the time, the dosage for the first six weeks of use is between four and eight milligrams, depending on a person’s body weight. Keep in mind that if you would like to make the peptide last a bit longer, you can pull the correct dosage of the reconstituted peptide into a syringe and freeze each dose for later use. When ready, you simply take it out of the freezer and let it thaw. However, you shouldn’t freeze it once it’s reconstituted.

There is a formula to help calculate the correct dosage for human use based on animal dosage. The formula is HED (mg/kg) = Animal dose (mg/kg) times (Animal Km divided by Human Km). For example, a person that weighs 200 lbs. would end up taking a dosage of 7.66mg. After the initial six-week period, it is common that instead of taking a dosage every week, it becomes every other week and lowers to between two and six milligrams per dose.

Paradigm Peptides: Your Source for Research on Healing Peptides & More

Now that you understand the background of TB-500 and all the benefits that come with taking this healing peptide, you can decide whether or not to buy TB-500 and continue your research. If you are interested in learning more about how TB-500 can improve your overall health and wellness, check out all the peptide products that Paradigm Peptides offers in the online store. If you have any questions and are interested in how you can use peptides for therapy? Browse Our Peptides Therapy guide, and feel free to reach out at any time for answers.


Explore the healing benefits of TB-500 for yourself. Whether it’s a new injury or chronic pain, TB-500 healing peptides have been shown to help in a variety of ways. Shop our online store and stock up on TB-500 to begin researching its capabilities today.

Buy TB-500 from Paradigm Peptides online.

21 thoughts on “TB-500: One of the Best Healing Peptides”

  1. So, should you take the 7.66 mg in 1 dose a week or break it up into several shots? I weigh 220 and am nursing a rotater cuff injury. Not sure how much to take.

    • Injection site is not important with this peptide ( TB-500 ) as it will quickly move systematically throughout the body

    • I am unaware of any studies preformed on the use of this peptide for erectile dysfunction.
      You may want to look into the peptide PT-141. It had many clinical trials regarding ED.

    • PT 141 is unbelievably amazing w erection issues. Whether its deep mental sexual anxiety of vascularity issues. After SQ injection it takes 3-5hrs for intense uncontrollable erections on and off that lasts for about 8-12 hours.

  2. Im confused as to whether or not I can freeze the peptide. At one point in this article is says that at no point do I want to freeze it but in another part it says I can freeze the reconstituted peptide for future use and then let it thaw…

    • We recommend storing the peptide in the freezer prior to reconstitution or mixing. After reconstitution ideally you would use the mixed peptide within a month and store in the refrigerator. It is possible to freeze certain peptides after mixed without damage to the peptide. In this instance TB500 would be okay to freeze and thaw before use. I would not recommend multiple freeze thaw cycles as this may lessen the potency. It is common in some instances of preloading syringes and freezing them and thawing to use as needed. Please note that this should not be done with hydrophobic peptides such as FRAG 176-191 as this will damage the peptide and it will loose potency. Hope this helps

  3. First time using a syringe…I accidently squirted all the sterile water into the tb500 vial…and not slowly as recommended….is this now rendered useless?

  4. Will using tb500 suppress natural production of thymosin beta 4? And is it safe for young people to use (30s) without disrupting natural healing cycles

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