How Sermorelin Peptides Are Related to Sleep

Medically Reviewed By: Johannah Gregg, DNP FNP-C

Sermorelin is a synthetic peptide that can help to enhance the abilities of both the pituitary and hypothalamic functions. In doing so, Sermorelin peptide therapy promotes an increased lean muscle mass as well as a reduction in fat, making it ideal for athletes and those who are looking to improve their body composition. Sermorelin therapy may also be helpful in promoting quicker wound healing as well. Here at Paradigm Peptides our peptides come as lyophilized powder that will need reconstitution. The Sermorelin comes as a 2mg vial with a purity of 99%.

How Sermorelin Peptides Are Related to Sleep

Sermorelin is a synthetic peptide that functions as a man-made version of the substance naturally produced by the body to stimulate human growth hormone release by the pituitary gland.

There are many different uses for Sermorelin, which is commonly used by children and adults who do not have healthy growth hormone levels (HGH levels) as a result of poor growth hormone production (HGH production).However, Sermorelin isn’t just useful for kids who need it to grow at a normal rate; this synthetic peptide offers benefits for everything from sleep and wound healing all the way to body fat reduction and an improved sex life.

When initially starting your search for the right peptide, there are several things to consider. For starters, what is it that you want to achieve from the use of your chosen peptide? If you’re looking for something that handles multiple areas of your health then you may want to think about Sermorelin.

Who is Sermorelin really right for? Well, are you someone that deals with anxiety or depression? Or perhaps you are experiencing a reduction in strength and muscle? Then Sermorelin is what you’re looking for. Better yet, are you someone who has experienced a disinterest in sex or been tired lately? Maybe you’re experiencing an increase in weight or reduced energy overall?

Maybe you’re experiencing fluctuations in hormones, as Johannah Gregg, Certified Family Nurse Practitioner and Peptide Therapy Specialist notes. Then yes, you’ll want to look into this quality peptide.

The Pituitary Gland And Hypothalamus

The pituitary gland is a small gland located near the bottom of your brain below the hypothalamus, which can be described as the “motherboard” of your brain. The pituitary gland and the hypothalamus work together to keep your body functioning properly in a state known as homeostasis. The pituitary gland has been deemed the “master gland” for quite some time. You can think of the pituitary gland like a puppet master working to regulate your body through its role in the endocrine system, which produces hormones.

The pituitary gland is responsible for the production and release of seven different hormones in the body, including:

Adrenocorticotropic hormone (ACTH or corticotrophin), which stimulates the production of cortisol. Cortisol is used to regulate metabolism, maintain blood pressure, regulate blood sugar levels, and reduce inflammation.
Follicle-stimulating hormone (FSH), which stimulates the production of sperm in biological males and the production of estrogen and egg development in biological females.
Growth hormone (GH), which plays a crucial role in increasing height in children and maintaining muscle and bone health in adults. It also influences the distribution of fat in the body and has a significant effect on metabolism.
Luteinizing hormone (LH), which stimulates ovulation in biological females and testosterone production in biological males.
Prolactin, which influences fertility and sexual functions in adults and stimulates the production of breast milk after birth.
Thyroid-stimulating hormone (TSH), which stimulates the thyroid to produce a host of hormones that have wide-ranging impacts, from managing metabolism, to supporting healthy energy levels, to maintaining a strong nervous system.

In addition to producing and releasing these hormones, the pituitary gland also directs other glands within the endocrine system to produce and release hormones. It does this by sensing what the body needs and sending out signals to the various glands and organs involved. In doing so, it controls your appetites, sexual abilities, and even your blood pressure. When taking Sermorelin, you’re essentially giving your pituitary gland an extra boost so that it functions even more optimally than before.

With the close proximity and interrelated function of the pituitary gland and hypothalamus, it’s probably no surprise that Sermorelin acts on both the pituitary gland and the hypothalamus. How so? Well for starters, if you look at the anatomy of the brain, the pituitary gland and hypothalamus are relatively close to one another. That being said, it is safe to say that the hypothalamus also plays an important role in the functioning of your body. One of the main things it regulates is your body temperature, but that’s not all. Much like the pituitary gland, the hypothalamus has some say in your sexual functions. However, where the pituitary gland is in charge of the maturation of your reproductive systems, the hypothalamus controls your sexual behaviors and emotions. By using Sermorelin, you’re giving your body extra help in many aspects of your health.

Other things that Sermorelin can accomplish include an increase in lean muscle mass, fat reduction, and improving your strength and stamina among other things.

What Is Sermorelin?

Sermorelin is a synthetic peptide whose brand name is Geref or Gerel; it is an analogue of growth hormone releasing hormone, or GHRH, meaning that it is bioidentical to the GHRH naturally produced by the pituitary gland. When used as a replacement or supplement for GHRH, Sermorelin stimulates the release of growth hormone from the pituitary gland. Sermorelin’s discovery can be traced back to the early 1980s, when it was discovered in the United States; the peptide was approved for use and sale by the FDA in 1997 for hormone replacement therapy, at which time the substance was primarily used as both a diagnostic tool and a treatment for growth hormone deficiency in both children and adults. However, for those that do not have a deficiency in growth hormone it can also be useful.

How Is Sermorelin Used?

Sermorelin is commonly used in an injectable form that is given before bed and is injected subcutaneously, or under the skin. Sermorelin is injected once per day, typically at night.

There are several different uses of Sermorelin in addition to the peptide’s common use in the treatment of human growth hormone deficiency in children and adults.

While these are the most common medical applications of Sermorelin, some research indicates that Sermorelin therapy may be helpful for people with certain types of recurring glioma, a type of brain tumor. Some studies also support the idea of using Sermorelin as a type of anti-aging therapy thanks to its ability to slow the aging process by increasing lean body mass, improving insulin sensitivity, promoting general well-being, and increasing libido.

Sermorelin can also be used to promote restful sleep; when people use Sermorelin peptides for sleep, they are simulating a process that is designed to stimulate the human body into releasing growth hormone on a level that it hasn’t since youth.

Sermorelin Benefits

With so many applications of Sermorelin, it’s no surprise that there are an impactful number of benefits of Sermorelin therapy for users of this popular peptide. In fact, Sermorelin can even provide benefits for a short time after use is discontinued. For starters, you can expect an increase in lean muscle mass and a reduction in fat. At the same time, you can also expect an improvement in not only your energy but your endurance and strength.

A study of Sermorelin in patients with recurrent brain cancer found that the use of Sermorelin positively impacts the immune system and provides an enhanced immune response, which means your overall health may experience a boost when using the peptide.

In addition to Sermorelin’s potential to have positive benefits on your physical health, Sermorelin may also improve mental health and brain function, including improved cognition and ability to remember, relief from depression, improved mood, and better sleep. People with reduced levels of naturally produced HGH often suffer from symptoms such as decreased brain function, depression, mood swings, lowered work capacity, self-isolation, and anxiety. When people suffer from depression, they commonly experience disruption in their normal sleep patterns as a result of lower levels of HGH, as the majority of the body’s HGH is released during sleep.

Benefits of Sermorelin can include the following:

Increased fat burn and healthier metabolism
Improved endurance, energy and strength
Thicker healthier skin and nails
Reduction of wrinkles and fine lines
Improved mood and a better quality of sleep
Increased libido
Faster wound recovery time and improved healing
Improved mental clarity
Improved memory and cognitive function
Enhanced immune system and cardiovascular health

Sermorelin Peptides for Sleep

Sermorelin peptides are typically injected. Once the peptides enter your system, sermorelin will stimulate the production of your own natural hormones. In particular, Sermorelin stimulates your body to produce growth hormone (GH).

With better sleep comes an improved outlook on life and more energy to greet the day. For those who continue to use Sermorelin, they may see a boost in muscle tone, or a leaner body with less fat. Keep taking Sermorelin, and those effects can produce healthier skin and a firmer tone.

The Science of Sleep

Each sleep cycle is actually a miraculous process. When you begin to feel sleepy, it’s actually an intricate process involving millions of cells, hormones, and complex molecules acting in complete symphony to produce a feeling of lethargy. Getting a good night’s rest is something many healthy people take for granted, but those who struggle with sleep issues know that it’s not as easy as it seems.

The way Sermorelin affects sleep is closely linked to the presence of orexins in your body. Orexins are a type of neuron that exist throughout the brain and spinal cord. Amazingly, there are only around 10,000 to 20,000 orexins that exist in a human body. It’s a small number when one considers that there are billions of brain cells. And yet, these tiny neurons do much of the heavy lifting when it comes to feeling asleep or awake.

Many people have been using Sermorelin peptides for effective sleep because these peptides have been scientifically proven to regulate the release of orexins when the body is having trouble doing it independently. It’s no surprise then that narcolepsy can be one effect for people who have inefficient levels of orexins in their systems.

More orexins (or the by-products of having more orexin) can lead to many other happy benefits in the body. For instance, Sermorelin may also be helping you to regulate weight loss, manage addiction, and stabilize excessive eating.

Sermorelin Side Effects

The most common side effects of Sermorelin injections include increased hunger as your metabolism accelerates and increased levels of cortisol in the body. Cortisol, also known as the stress hormone, is the way your body naturally responds to stress and is responsible for the fight or flight instinct.

Less common side effects associated with Sermorelin use may include dizziness, headache, sleepiness, redness of the face or neck, difficulty sitting still, changes in taste, and injection site reactions. However, these side effects are rare and Sermorelin is well-tolerated in most people.

If your side effects persist after several months of Sermorelin use or are particularly troublesome, you may want to speak with a doctor about continuing your regimen.

Who Should Not Use Sermorelin?

Research has shown that Sermorelin use is generally safe and well-tolerated by most people. However, there are several groups of people who should not use Sermorelin without first consulting with a doctor.

These groups include:

People with a known allergy to Sermorelin
Women who are pregnant
Women who are planning to become pregnant
Women who are breastfeeding
People with untreated hypothyroidism (low thyroid)

If you have any questions regarding whether Sermorelin use is safe for you or if you have been diagnosed with medical conditions that may affect the peptide’s effectiveness or safety, consult with your doctor before beginning injections of Sermorelin. Your doctor should also be able to provide information and medical advice about the appropriate dose of Sermorelin for your goals.

Sermorelin Results Timeline

As with many synthetic peptides, it may take time to see results from Sermorelin. However, the most common results for the first six months of use are listed below.

1 to 3 Months

In the first few months, you’ll start to notice an increase in both energy and stamina. This will be in part because of Sermorelin’s ability to help with restful sleep, promote increased cognitive function, and support a healthy mood. Not only that, you may also notice that your metabolism is working more efficiently. Common signs of an increased, more efficient metabolism include increased hunger as a result of your body burning off excess fat stores, allowing you to more easily manage your weight. Other results you may notice in the first one to three months of use include a reduction in fine lines and wrinkles paired with stronger, healthier skin and nails and an increase in sex drive. Last but not least, because of its ability to accelerate wound healing and support immune function, you may also see an improvement in joint pains and overall health when using Sermorelin.

4 to 6 Months

While the first one to three months of Sermorelin use are likely to provide a sharp increase in noticeable health benefits, the subsequent three months of Sermorelin use typically continue the positive trajectory and provide more consistent results. In addition to the overall benefits for mental and physical health, you are more likely to see the increase in lean muscle mass and improvement in body composition as well as a consistency in your weight loss during months four through six of use.

Sermorelin – Using The Right Dose

Choosing the right dose of Sermorelin depends on your goals and factors such as your age and weight. As a rule of thumb, most people find that a dose of 250 mcg to 500 mcg is enough to help them experience the benefits they hope to achieve through Sermorelin use. These numbers convert to roughly 0.25MG to 0.5MG per injection. When first beginning a Sermorelin regimen, it is typically recommended to start on the lower end of this dosing protocol as the dose will depend on many factors, such as your height, weight, age, and your physical and mental health.

Consider starting with the lowest recommended dose of Sermorelin in order to see how your body reacts to the peptide, and increase your dose incrementally as needed in order to achieve your desired results. The best time to take Sermorelin is before bed as this coincides with your body’s ability to produce its own growth hormone and helps to maximize the benefits of Sermorelin for sleep, physical health, and mental health.

Buy Sermorelin From Paradigm Peptides

Buying peptides can be tricky. There are dozens of manufacturers online that boast the best of the best, but the search can get a bit overwhelming. That’s where Paradigm Peptides can help. We carry top quality pharmaceutical grade peptides. Each one is stringently tested to ensure efficacy and purity so that you know you are getting the best. Have questions about our peptides or other products? Our friendly customer service team is here ready to help you. Reach out today!

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Disclaimer: The Sermorelin currently listed on this site is sold for research use only. Not for human consumption. This product is not a drug, supplement, food or cosmetic and it may not be misused, sold, labeled or branded as such. These products are not intended to diagnose, treat, or cure any condition or disease. It is not intended for human consumption, and is for research purposes only.